Apoptosis and Cell Death Research at the Burham Institute
Research includes studies of Bcl-2 family proteins, caspases and
their activators and inhibitors, studies of mitochondrial involvement
in cell death, signal transduction mechanisms used by TNF-family
cytokine receptors, as well as survival signals delivered through
integrins, growth factor receptors and oncoproteins. This group
is currently hosting the Apoptosis
Database.
Alan G. Porter's group at the Institute of Cell and Molecular Biology
(IMCB), Singapore
The group focuses on investigating caspases as
well as the targets of specific transcription factors in mammalian
cell death and differentiation. The group is performing microarrays
and targeted knock out of caspase and other apoptosis-related genes
in human tumour cells in order to study their functions in detail,
particularly in apoptotic stress responses.
The
Horvitz's Laboratory (MIT, Howard Hughes Medical Institute, McGovern
Institute for Brain Research)
Led by Principal Investigator, H. Robert Horvitz, the group works
on programmed cell death as well as signal transduction, morphogenesis,
micro RNAs, neural development etc.
Junying Yuan's
group at the Department of Cell Biology, Harvard Medical School
Professor Yuan was among the pioneers in the discovery of caspases
and their role in apoptosis.
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